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Research library/DIM
General Health · Ingredient guide

DIM

3,3′-Diindolylmethane is a cruciferous-vegetable metabolite studied mainly for hormone and tissue biomarkers.

Compare
Evidence strengthInsufficient evidence
Based on consistency, quality and relevance of human research—not podcast mentions.
Common research protocol100–300 mg/day absorption-enhanced DIM in biomarker trials
Protocols mapped1 goal-specific protocol
Evidence reviewed throughSeptember 2026
Evidence verdict

Insufficient evidence for the stated context. Biomarker changes do not prove cancer prevention or hormone balance, and DIM lowered active tamoxifen metabolites in one randomized trial.

Scientific evidence1 reviewed sourceDetermines the evidence grade
Expert & media context0 reviewed sourcesDoes not change the grade alone
01

What it is & primary uses

3,3′-Diindolylmethane is a cruciferous-vegetable metabolite studied mainly for hormone and tissue biomarkers.

Estrogen-metabolism biomarkersBreast-health researchProstate biomarker research
02

Main benefits

  • Trials show changes in estrogen metabolites and sex-hormone-binding globulin.
  • Biomarker changes do not prove cancer prevention or hormone balance, and DIM lowered active tamoxifen metabolites in one randomized trial.
03

Studied protocols

Research doses are grouped by outcome. They describe study designs—not a personal prescription.

Estrogen-metabolism biomarkers

100–300 mg/day absorption-enhanced DIM in biomarker trials

Very low confidence
Study duration
Commonly 4–12 weeks; protocol and outcome vary
Interpretation
Biomarker changes do not prove cancer prevention or hormone balance, and DIM lowered active tamoxifen metabolites in one randomized trial.

Clinical or experimental context—professional guidance is especially appropriate.

04Food sources & equivalents
Food sources & equivalents

Can food provide a studied amount?

No direct food equivalent
Comparison target100–300 mg/day absorption-enhanced DIM in biomarker trials

DIM in this supplemental form does not have a reliable one-to-one food equivalent.

Cruciferous vegetables provide indole-3-carbinol precursors, not a predictable DIM supplement doseFood amount varies

Dietary exposure; verify composition before comparing with a studied supplement dose

How this was estimated
Dose Radar compares the declared active ingredient with official composition data or the studied standardized extract—not with marketing names.
Important limitation
Natural content, preparation, bioavailability and formulation vary. This comparison does not prove equal physiological effect.

Food equivalents compare ingredient mass using published composition values. They do not prove equal absorption, formulation, physiological effect, safety or personal need.

Source: DIM with tamoxifen biomarker trial ↗
05How to take it for absorption & tolerance
Meal relationship

With food

Evidence-informed
With food; formulation and tolerance remain part of the comparison.

Food commonly improves gastrointestinal tolerance, although it can change absorption for some ingredients.

Practical approach
With food and only in the trial-matched formulation. Keep the formulation and daily total consistent with the evidence context shown above.
Watch for
Tamoxifen

Meal guidance reflects human pharmacokinetic, clinical, official-label or evidence-review sources where available. A food pairing can change absorption or tolerability, but does not make a supplement necessary, effective or safe for every person.

Source: DIM with tamoxifen biomarker trial ↗
06Supplement interaction check
Library interaction context156 ingredients · 0 mapped signals for this guide

An unlisted pair means no established pair-specific interaction was identified in this review—not proof that every dose, product or person is safe.

No pair-specific signal listedNo established interaction with another Dose Radar ingredient was identified in this review.

This is not proof that every dose, product or user context is safe. Medication and condition checks still apply.

07Research notes
Evidence verdict

Insufficient evidence for the stated context. Biomarker changes do not prove cancer prevention or hormone balance, and DIM lowered active tamoxifen metabolites in one randomized trial.

The displayed amount comes from human research or an official evidence summary. It is not a personalized prescription, and formulation can change whether the comparison is valid.

TimingWith food and only in the trial-matched formulation
Time to expected effectStudy-specific; commonly several weeks
08Scientific references
Evidence sourceUsed to assess efficacy, protocols and confidence

Peer-reviewed human research and formal evidence reviews. Open each source to inspect the complete paper record.

Scientific evidence2026Official evidence summary↗ PubMed

DIM with tamoxifen biomarker trial

Dose context: 100–300 mg/day absorption-enhanced DIM in biomarker trials

Trials show changes in estrogen metabolites and sex-hormone-binding globulin. Biomarker changes do not prove cancer prevention or hormone balance, and DIM lowered active tamoxifen metabolites in one randomized trial.

09Expert & media references
Context sourceUsed to understand what professionals discuss

Podcast and practitioner statements are clearly separated from research. They may explain practice or emerging ideas, but do not prove efficacy.

0 reviewed context sourcesNo verified expert or media reference mapped yet.

Dose Radar will leave this lane empty rather than invent or infer a professional opinion.