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Research library/Palmitoylethanolamide (PEA)
General Health · Ingredient guide

Palmitoylethanolamide (PEA)

An endogenous fatty-acid amide available in micronized formulations and studied as an adjunct for chronic pain.

Compare
Evidence strengthModerate evidence
Based on consistency, quality and relevance of human research—not podcast mentions.
Common research protocol600–1,200 mg/day micronized or ultramicronized PEA in many pain studies
Protocols mapped1 goal-specific protocol
Evidence reviewed throughSeptember 2026
Evidence verdict

Moderate evidence for the stated context. Formulation, diagnosis and study quality vary, and the optimal dose and duration remain uncertain.

Scientific evidence1 reviewed sourceDetermines the evidence grade
Expert & media context0 reviewed sourcesDoes not change the grade alone
01

What it is & primary uses

An endogenous fatty-acid amide available in micronized formulations and studied as an adjunct for chronic pain.

Chronic-pain researchNeuropathic-pain researchInflammatory-pain research
02

Main benefits

  • Meta-analyses of randomized trials report lower pain scores across selected chronic-pain populations.
  • Formulation, diagnosis and study quality vary, and the optimal dose and duration remain uncertain.
03

Studied protocols

Research doses are grouped by outcome. They describe study designs—not a personal prescription.

Chronic-pain research

600–1,200 mg/day micronized or ultramicronized PEA in many pain studies

Moderate confidence
Study duration
Commonly 4–12 weeks; protocol and outcome vary
Interpretation
Formulation, diagnosis and study quality vary, and the optimal dose and duration remain uncertain.
04Food sources & equivalents
Food sources & equivalents

Can food provide a studied amount?

No direct food equivalent
Comparison target600–1,200 mg/day micronized or ultramicronized PEA in many pain studies

Palmitoylethanolamide (PEA) in this supplemental form does not have a reliable one-to-one food equivalent.

Small endogenous and dietary exposure is not equivalent to a micronized supplementFood amount varies

Dietary exposure; verify composition before comparing with a studied supplement dose

How this was estimated
Dose Radar compares the declared active ingredient with official composition data or the studied standardized extract—not with marketing names.
Important limitation
Natural content, preparation, bioavailability and formulation vary. This comparison does not prove equal physiological effect.

Food equivalents compare ingredient mass using published composition values. They do not prove equal absorption, formulation, physiological effect, safety or personal need.

Source: PEA for chronic pain ↗
05How to take it for absorption & tolerance
Meal relationship

With or without food

Evidence-informed
With or without food; formulation and tolerance remain part of the comparison.

Human research has not established a universally superior fed or fasted protocol for this ingredient.

Practical approach
Once or twice daily according to the trial-matched formulation. Keep the formulation and daily total consistent with the evidence context shown above.
Watch for
Medication interactions are not well mapped

Meal guidance reflects human pharmacokinetic, clinical, official-label or evidence-review sources where available. A food pairing can change absorption or tolerability, but does not make a supplement necessary, effective or safe for every person.

Source: PEA for chronic pain ↗
06Supplement interaction check
Library interaction context156 ingredients · 0 mapped signals for this guide

An unlisted pair means no established pair-specific interaction was identified in this review—not proof that every dose, product or person is safe.

No pair-specific signal listedNo established interaction with another Dose Radar ingredient was identified in this review.

This is not proof that every dose, product or user context is safe. Medication and condition checks still apply.

07Research notes
Evidence verdict

Moderate evidence for the stated context. Formulation, diagnosis and study quality vary, and the optimal dose and duration remain uncertain.

The displayed amount comes from human research or an official evidence summary. It is not a personalized prescription, and formulation can change whether the comparison is valid.

TimingOnce or twice daily according to the trial-matched formulation
Time to expected effectStudy-specific; commonly several weeks
08Scientific references
Evidence sourceUsed to assess efficacy, protocols and confidence

Peer-reviewed human research and formal evidence reviews. Open each source to inspect the complete paper record.

Scientific evidence2026Official evidence summary↗ PubMed

PEA for chronic pain

Dose context: 600–1,200 mg/day micronized or ultramicronized PEA in many pain studies

Meta-analyses of randomized trials report lower pain scores across selected chronic-pain populations. Formulation, diagnosis and study quality vary, and the optimal dose and duration remain uncertain.

09Expert & media references
Context sourceUsed to understand what professionals discuss

Podcast and practitioner statements are clearly separated from research. They may explain practice or emerging ideas, but do not prove efficacy.

0 reviewed context sourcesNo verified expert or media reference mapped yet.

Dose Radar will leave this lane empty rather than invent or infer a professional opinion.